Natural Inhibitors of Influenza Infection

Grant number: 1032079 | Funding period: 2012 - 2014

Completed

Abstract

This study will characterize the ability of soluble proteins in airway secretions to recognize and destroy influenza viruses. As many of our insights regarding influenza pathogenesis are derived from studies in animal models, we will characterize the importance of proteins in airway fluids from mice and ferrets, as well as from humans. These findings will be of particular importance when assessing the relevance of particular animal models to understanding human disease.

Related publications (7)

Neutralizing inhibitors in the airways of naïve ferrets do not play a major role in modulating the virulence of H3 subtype influenza A viruses

ER Job, A Pizzolla, T Nebl, KR Short, YM Deng, L Carolan, KL Laurie, AG Brooks, PC Reading

2016-07-01

Many insights regarding the pathogenesis of human influenza A virus (IAV) infections have come from studies in mice and ferrets. S..

Playing hide and seek: How glycosylation of the influenza virus hemagglutinin can modulate the immune response to infection

MD Tate, ER Job, YM Deng, V Gunalan, S Maurer-Stroh, PC Reading

2014-03-14

Seasonal influenza A viruses (IAV) originate from pandemic IAV and have undergone changes in antigenic structure, including additi..

A single amino acid substitution in the hemagglutinin of H3N2 subtype influenza a viruses is associated with resistance to the long pentraxin PTX3 and enhanced virulence in mice

ER Job, B Bottazzi, KR Short, YM Deng, A Mantovani, AG Brooks, PC Reading

2014-01-01

The long pentraxin, pentraxin 3 (PTX3), can play beneficial or detrimental roles during infection and disease by modulating variou..

Serum Amyloid P Is a Sialylated Glycoprotein Inhibitor of Influenza A Viruses

ER Job, B Bottazzi, B Gilbertson, KM Edenborough, LE Brown, A Mantovani, AG Brooks, PC Reading

2013-03-27

Members of the pentraxin family, including PTX3 and serum amyloid P component (SAP), have been reported to play a role in innate h..

Addition of glycosylation to influenza a virus hemagglutinin modulates antibody-mediated recognition of H1N1 2009 pandemic viruses

ER Job, YM Deng, KK Barfod, MD Tate, N Caldwell, S Reddiex, S Maurer-Stroh, AG Brooks, PC Reading

2013-03-01

Seasonal influenza A viruses (IAV) originate from pandemic IAV and have undergone changes in antigenic structure, including additi..

The "sweet" side of a long pentraxin: How glycosylation affects PTX3 functions in innate immunity and inflammation

A Inforzato, PC Reading, E Barbati, B Bottazzi, C Garlanda, A Mantovani

2013-01-01

Innate immunity represents the first line of defense against pathogens and plays key roles in activation and orientation of the ad..

Soluble host defense lectins in innate immunity to influenza virus

WC Ng, MD Tate, AG Brooks, PC Reading

2012-06-20

Host defenses against viral infections depend on a complex interplay of innate (nonspecific) and adaptive (specific) components. I..

University of Melbourne Researchers

Patrick Reading